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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INNTooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family.[5][1][4][2] It is found in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado River toad.[5] It may occur naturally in humans as well.[5] Like its close relatives dimethyltryptamine (DMT) and bufotenin (5-HO-DMT), it has been used as an entheogen in South America.[5][6] Slang terms include five-methoxy, the power, bufo, and toad venom.[7] The drug has been described as the most powerful psychedelic[8][9] and, by Michael Pollan, as the “Mount Everest of psychedelics”.[9]
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The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT1A and 5-HT2A receptors among others.[1][4][10] However, 5-MeO-DMT differs from most other serotonergic psychedelics in having 100- to 1,000-fold higher affinity for the serotonin 5-HT1A receptor over the serotonin 5-HT2A receptor.[1][4][10] In relation to this, 5-MeO-DMT has been described as an “atypical” psychedelic and as producing subjective effects notably distinct from those of DMT and other psychedelics, for instance having a relative lack of visual effects.[5][1][4] Like DMT, 5-MeO-d has a very rapid onset of action and short duration.[1][4] However, 5-MeO-DMT is 4- to 10-fold more potent than DMT in humans